Microcatheters Market Share, Trend, Challenges and Segmentation | Forecast to 2027

 Market Highlights

According to MRFR analysis, the global microcatheters market is expected to register a CAGR of~4.1% from 2021 to 2027and hold a value of ~USD 2,412.0 million in 2027.

The global microcatheters market is driven by several factors, such as a rise in the prevalence of chronic diseases such as neurovascular, cardiovascular, and urology disorders, increased adoption of minimally invasive procedures, and development of new diagnostic centers and hospitals in developing regions. According to WHO, 17.9 million people die each year due to cardiovascular diseases, an estimated 31% of all deaths worldwide. The inclination toward minimally invasive surgeries is increasing due to its less risk than traditional surgeries because it uses smaller surgical incisions. Thus, the above-mentioned factors collectively are fueling the microcatheter market growth.

The industry players are launching new microcatheters with advanced technologies in the market. The companies are making high investments in R&D to launch unique products in the market. They are also making partnerships and acquisitions in the regions for future expansion. For instance, in March 2021, Boston Scientific (US) announced that it entered a definitive agreement with an affiliate of Baring Private Equity Asia (BPEA) to acquire the global surgical business of Lumenis Ltd (Israel), a privately-held company that develops and commercializes energy-based medical solutions.

Regional Analysis

North America is expected to dominate the microcatheters market throughout the study period, owing to the growing geriatric population, increasing number of percutaneous coronary intervention procedures, availability and accessibility to technologically advanced products, and increasing government initiatives. According to the US Census Bureau, the US constitutes 34% of the population aged 65 or older, which has increased by 3.2% over a year. Among the different regions in North America, Maine ranks first with the highest geriatric population. An increased aging population leads to a rise in the number of people suffering from chronic diseases, which results ina high number of surgeries performed. This is increasing the demand for microcatheters across the region. Increasing investments in the development of advanced microcatheter to reduce complications during the surgical procedure have surged the level of competition amongst the market players. Moreover, the competitors are launching devices integrated with advanced technologies.

Europe holds the second-largest position in the microcatheters market due to the high demand for technologically advanced products and increased adoption of minimally invasive surgery across the region. In addition, countries such as Italy, Germany, France, Spain, and the UK have a large geriatric population, which is expected to support market growth.

Asia-Pacific is anticipated to be the fastest-growing regional market over the forecast period due to the presence of a large patient pool, increasing prevalence & incidence of target diseases, and growing healthcare infrastructure in Asian Countries. Moreover, other factors supporting the microcatheter market include increasing healthcare spending and government initiatives for strengthening the healthcare infrastructure.

The growth of the market in the Rest of the Worldis attributed to the technological advancements in microcatheters coupled with the expansion of distribution channels throughout the region.

Segmentation

The global microcatheters market has been segmented into design, product, application, and end use.

By design, the market has been segregated into single lumen and double lumen. The double lumen segment is expected to hold a considerable share of the market in 2020. The double lumen has various advantages, such as easy access to the procedural site. Increasing preference for interventional cardiology procedures of dual lumen microcatheter will augment the market growth in the assessed time period.

Based on application type, the global microcatheters market has been classified as cardiovascular, neurovascular, peripheral vascular, oncology, and urology. The cardiology segment held the largest segment share in 2020, owing to the rise in the prevalence of chronic diseases such as cardiovascular disorders across the globe.

Based on end user, the microcatheters market is classified into hospitals, specialized clinics, and ambulatory surgical centers. The hospitals segment held the largest market share in 2020 due tothe rise in the prevalence of target diseases and many surgical and diagnostic procedures performed across these facilities.

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Key Players

Some of the key players in the global microcatheters market are Medtronic (US), Boston Scientific (US), Terumo Medical Corporation (US), Teleflex Inc. (US), Merit Medical Systems, Inc. (US), Guerbet (France), Cook Medical (US),Acandis GmbH (Germany), Acrostak (Switzerland), Stryker Corporation (US), Asahi Intecc (Japan), Lepu Medical Technology Company (China), and Cerus Endovascular Ltd (US).

 

Biopharmaceutical Excipients Market Opportunities, Trends and Future Outlook By 2027

 Market Highlights

According to MRFR analysis, the global biopharmaceutical excipients market is expected to register a CAGR of~6.8% from 2021 to 2027and is expected to hold a value of ~USD 3,114.6 million by 2027.

The global biopharmaceutical excipients market is driven by several factors, such as increasing demand for oral formulations across the globe, rising demand for customized medicines, and an increasing geriatric population. Other factors such as increasing patients with chronic ailmentscoupled with growing life expectancy are driving the production of biopharmaceuticals. In addition, increasing stress, back pains, body aches, and headaches has augmented the demand for topical type formulation, accelerating the market growth.

The industry players focus on expanding their global footprint by strategic partnerships, investing in some company’s stock, acquisitions, and product launches. For instance, in February 2020, ReForm Biologics (US) partnered with MilliporeSigma (US) to commercialize excipients used in biotherapeutics. In August 2019, LBB Specialties (US) announced the strategic partnership with MEGGLE (Germany)to expand its excipient distribution channel across the US. In December 2018, Roquette (France) bought a majority stake in excipient producer Crest Cellose (India) that enabled the company to expand its product portfolio and presence in the Indian generic pharmaceutical market. Furthermore, the prominent players focus on new developments, employee satisfaction, the transformation of their research wings, and expanding their distribution network. These factors will augment the market growth and will increase theproduct demand in the forecast timeline.

Regional Analysis

North America is projected to dominate the biopharmaceutical excipients market due to the growing adoption of the latest drug manufacturing technologies, increasing chronic diseases, and expansion of production capabilities of the industry players across the region. In addition, high investments were made in the development of new excipient variants to advance the product portfolio. Furthermore, the key players are involved in collaborations, mergers, and R&D activities that propel market growth.   

Europe embraces the second-largest position in the biopharmaceutical excipients market due to growing investments in the pharmaceutical sector and increasing production capacity across the region. In addition, the region experienced high demands for pharmaceutical products. Moreover, countries such asGermany, Italy, the UK, France, and Spain have invested huge amounts in the manufacturing of new vaccines.

Asia-Pacific is anticipated to be the fastest-growing regional market over the projected timeline due to the rising investment in pharmaceutical research and production facilities, increasing consumption of medicines, and supportive government alliances and subsidy schemes. In addition, the availability of highly skilled research employees and an economical workforce is creating opportunities for the industry players.

Furthermore, the market in the Rest of the World is gaining importance due to the rising number of investors, growing geriatric population in countries such as Chile and Argentina, and expansion of the pharmaceutical market across Latin America. However, the availability of counterfeit pharmaceutical goods is hampering the biopharmaceutical excipient market. The pharmaceutical companies aim atinvesting in the Middle East & Africaregion owing to its technologically advanced labs and other research infrastructures. Countries such as Saudi Arabia and the UAE are hiring employees throughout the globe to advance their pharmaceutical market.

Segmentation

The global biopharmaceutical excipients market is categorized into product and formulation. Based on the product category, the market has been segregated into solubilizers & surfactants/emulsifiers, polyols and carbohydrates, and specialty excipients. The carbohydrates segment is expected to hold a considerable share of the market in 2021. Increasing R&D activities for the development of lipid and protein excipient-based corona vaccines is fueling the market demand. In addition, the high demand for carbohydrate-based medicines for the infant segment is propelling the biopharmaceutical excipient market.

Based on formulation, the global biopharmaceutical excipients market has been classified as oral, topical, and injectables. The oral segment held the major share in 2020 due to the easy intake procedure and availability of oral medicines throughout the hospitals and retail stores. Additionally, the demand for oral and topical formulations is accelerating due to the growing preference for on-the-go treatment and ambulatory treatment services coupled with increasing cases of trypanophobia.

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Key Players

Some of the key players in the global biopharmaceutical excipients market are Merck KGaA (Germany), Colorcon (BPSI Holdings Inc) (US), BASF SE(Germany), Associated British Foods plc (UK), Signet Excipients Pvt. Ltd (IMCD) (Netherlands), Sigachi Industries Limited (Hyderabad), Spectrum Chemical Manufacturing Corp. (US), Roquette Frères (France), Clariant (Switzerland), DFE Pharma (Germany), J. Rettenmaier & Söhne Gmbh + Co Kg (Germany), and Evonik Industries AG (Germany).

 

Cellulite Treatment Market Growth, SWOT Analysis and Growth Prospects To 2027

 Market Highlights

According to MRFR analysis, the global cellulite treatment market is expected to register a CAGR of11.2% from 2020 to 2027and hold a value of USD 3,162.1 million by2027.

The global cellulite treatment market is driven by several factors, such asintake of an unhealthy diet, long working hours in a similar posture, minimum physical exercise, genetics, and an increasing geriatric population. Moreover, the market players are developing products to restructure epidermal tissueto augmentthe market demand. For instance, MCCM Limited offers MCCM DNA for cellulite treatment. It is a biologically active ingredient that promotes the re-organization of epidermal tissues owing to its high regeneration properties. The application of MMCM ADNA increases skin elasticity offering the firmer appearance of the skin. The emergence of such products drives the market demand, fueling industry growth across the globe.

The industry players focus on expanding their distribution network and supply chain to dominate the global cellulite treatment market. The key players focus on new product launches, strategic agreements, and joint ventures to augment their market positions. For instance, in October 2019, Merz announced the launch of  Cellfina, a cellulite treatment approved by the FDA. The cellulite treatment in the buttocks and thighs of adult females is highly effective and lasts for five years. The launch of such treatment procedures will increase customer satisfaction and provide a wide variety of options for cellulite treatment.

Regional Analysis

North America is expected to dominate the cellulite treatment market, owing to the growing genetic diseases, adoption of the latest technologies for cellulite treatment, and expansion of operation facilities of the industry players across the region. In addition, increasing investments in the development of advanced devices to minimize cellulite formation have surged the level of competition amongst the market players. Moreover, the competitors are launching devices integrated with advanced technologies such as infrared light, radiofrequency and ultrasound, etc. Furthermore, the prominent players are involved in collaborations, partnerships, and R&D are a few of the factors driving the market growth.    

Europe holds the second-largest position in the cellulite treatment market due to the growing demand for cosmetic treatment across the region. In addition, countries such as  Germany, Sweden, UK, France, and Switzerland have a large number of patients that undergo cosmetic treatment to get a sculpted body.

Asia-Pacific is anticipated to be the fastest-growing region over the forecast period due to increasing investment in healthcare infrastructure, rising number of feminine population, and growing physical fitness awareness among the working population. In addition, the availability of qualified dermatologists for consultation and treatment is creating opportunities for the industry players.

Furthermore, the growth of the market in the rest of the world is attributed to the technological advancements in cellulite treatment and the expansion of distribution channels throughout the region. For instance, Lumenis Ltd. announced the NuEra Tight with FocalRF technology available in Europe and the Middle East for skin tightening, fat reduction, cellulite, and wrinkle reduction. Such initiatives are driving the market growth of cellulite treatment in the MEA region.  

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Segmentation

The global cellulite treatment market has been segmented into treatment procedure, cellulite type, and end use. By treatment procedure, the market has been segregated into non-invasive, minimally-invasive, and topical treatment. The non-invasive segment is expected to hold a considerable share of the market in 2020. Increasing use of radiofrequency, infrared, and ultrasound technology for cellulite reduction will augment the market growth in the assessed time period.

Based on cellulite type, the global cellulite treatment market has been classified as hard cellulite, soft cellulite, and edematous cellulite. Soft cellulite held the largest segment share in 2020, owing to the increasing number of overweight and obese people across the globe.

Based on end use, the cellulite treatment market is classified into hospitals, specialized dermatology clinics, and ambulatory surgical centers. Specialized dermatology clinics held the largest market share in 2020 due to the availability of skilled doctors, high efficacy rate, and better treatment infrastructure.

Key Players

Some of the key players in the global cellulite treatment marketareNubway (China), Merz Pharma GmbH & Co. KGaA (Germany), Beijing Sincoheren S & T Development Co., Ltd, (China), Cymedics (Germany), Cynosure, Inc. (U.S), IncelerMedikal Co. Ltd. (Turkey), Tanceuticals, LLC. (U.S), Zimmer Aesthetics (Germany), Syneron Medical Inc  (U.S), Candela Medical (U.S), Hologic Inc. (U.S), Cutera (U.S), Skinrex Co., Ltd. (South Korea).

 

 Market Research Future published a raw research report on the global medical device cleaning market that contains the information from 2020–2026.  The global medical device cleaning market is expected to grow at 7.2% CAGR during the forecast period, 2020-2026.

Taste the market data and market information presented through more than 83 market data tables and figures spread in 140 numbers of pages of the project report. Avail the in-depth table of content & market synopsis on “Global medical device cleaningMarket Information from 2019 to 2026."

The global medical device cleaningmarket size is projected to reach USD 4.1 Billion by 2026, with 7.2% CAGR during the forecast period.

Medical devices after their certain use needs to be sterile. This is done for the motive of providing the safety to patients and further avoids infections at the site of wound, and incisions. Moreover, the cleaning of the surgical instruments is more crucial and critical task than cleaning other non-medical devices. The surgical instruments are stained with blood, organic materials pus, tissue, and others things which may cause infections to others during its reuse. Therefore, to clean and make the medical devices disinfectant, the medical device cleaning products are used.

The infections acquired through the hospitals are believed to be one of the major concerns that is affecting many patient’s recovery. This also has a major impact on mortality rates worldwide. According to the WHO, the prevention of HAIs, the rising in the duration of hospitalization of persons suffering from HAIs was around approximately 8 days. Therefore, the prolonged stays are a significant contributor to the overall costs incurred during hospitalization. Hence, the growing clinical urgency to adopt various measures for the prevention of such infections is necessary. Prolonged hospital stays of the patients are also not economical for patients, hospitals and healthcare payers due to high usage of resources for the treatment of the acquired infections.

Industry News

• In April 2020, the U.S. FDA has approved the use of maX2, &maX low-temperature, Steris V-PRO 1 Plus, sterilization systems for decontamination of approximately 750,000 N95 respirators and similar masks each day in hospitals used for the treatment of Covid-19 patients amid the pandemic. This is expected to grow the goodwill of the company in the global market.
  
  

In 2020, the automatic cleaning segment is expected to dominate the market during the forecast period: MRFR

By Process:

On the basis of process, the market is segmented into disinfection, automatic cleaning, manual cleaning, and presoak/precleaning. Among these, the automatic cleaning segment is expected to grow with the highest CAGR during the forecast period. The automatic washer maximizes the productivity and minimum time requirement provided by the automotive washers are the key factors responsible for the growth of this segment in 2020.

By Application:

Based on application, the market is segmented into surgical instruments, endoscopes, ultrasound probes, dental instruments, and other instruments. Among these, the surgical instruments are expected to account for the largest share in medical device cleaning market in the year 2020. The growing prevalence and increasing burden of HAIs and chronic diseases, rising geriatric population, and an growth in the number of surgeries are the primary factors driving the use of surgical instruments, which is expected to boost the demand for effective cleaning and disinfection solutions during the forecast period.

By End Users:

Based on end users, the market is segmented into diagnostic centers, hospitals and clinics, dental clinics and hospitals, and other end users. The rising number of clinics and hospitals in various developed countries such as US and Germany is responsible for the larger market share of this segment. Hospitals and clinics are expected to show a growth at the highest CAGR during the forecast period in the medical devices cleaning market.

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The major players operating in the global Medical Device Cleaning market are 3M Company (US), Advanced Sterilization Products (US), Pharmax Ltd. (Canada), Stryker Corporation (US), Medline Industries Inc. (US), STERIS plc (US), Getinge Group (Sweden), Cantel Medical Corporation (US), Ecolab Inc. (US),  Ruhof Corporation (US), Metrex Research, LLC (US), Hartmann Group (Germany), Oro Clean Chemie AG (Switzerland), Integra LifeSciences Holdings Corporation (US), Sklar Surgical Instruments (US), Biotrol International (US), G9 Chemicals (UK), Medalkan (Greece), Case Medical Inc. (US), and Certol International LLC (US).

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This research report provides insights into various levels of analysis, such as industry analysis and market share analysis for the leading industry competitors, along with their profiles. It also helps in studying the target segments by providing views on the emerging and high-growth segments. The market data comprises the basic assessment of the competitive scenarios and strategies in the global medical device cleaningmarket, including high-growth regions and/or countries, and political and economic environments. The project report further provides both – historical market values and pricing and cost analysis.

Active Pharmaceutical Ingredient for Cancer Market Overview, Future Outlook and Share Analysis Till 2027

 Market Highlights

The Global Active Pharmaceutical Ingredient (API) for Cancer Market is expected to grow significantly over the forecast period. The API for cancer market held a valuation of USD 19,500.00 million in 2018 and is projected to register a CAGR of 8.1% over the forecast period.

The increasing participation of key players is one of the key factors driving the API for cancer market. For instance, various cancer drugs manufacturers such as Johnson & Johnson received US Food and Drug Administration approval for product Balversa (erdafitinib), oral fibroblast growth factor receptor (FGFR) kinase inhibitor in April 2019.

Various other factors that are driving the API for cancer market are rising FDA approvals of anticancer drugs, growing demand for newly developed small molecules drugs.

However, the side-effects of chemotherapy may hamper market growth over the forecast period.

Segmentation

The global API for cancer market is segmented based on product, type, indications, end users, and region.

Based on type, API for cancer market is segmented into Tinib, Parib, rafenib, Lisib, Degib, Ciclib, and others

Based on the indication, the market is segmented into blood cancer, skin cancer, lungs cancer, breasts cancer, pancreas cancer, others. Anti-cancer drugs are available in the market to treat various types of cancer. The chemotherapy is preferred for treatment. As per the report World Health organization in 2018 among the types of cancer lung cancer is responsible for the largest number of deaths about 1.8 million deaths which is 18.4% of the total number of prevalence worldwide. Thus, the lung cancer segments have higher growth compared to the other indications in this segment. Based on end user, the market is segmented into pharmaceutical companies, research organizations, others. Pharmaceutical companies’ major consumer of API for cancer. There is larger number of manufacturers producing anti-cancer products. The API has compounded the excipients into the desired dosage forms. The pharmaceutical companies segment holds the major share in this segment as it deals with a larger number of pharmaceutical companies compared to research organizations.

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Regional Analysis

In the current scope of the study, the segments mentioned above are covered into the four global regions, namely, the Americas, Europe, Asia-Pacific, and the Middle East and Africa.

The global API for cancer market in the Americas has further been segmented into North America and South America, with the North American market divided into the US and Canada.

The European global API for cancer market has been segmented into Western Europe and Eastern Europe. Western Europe has been classified as Germany, France, the UK, Italy, Spain, and the rest of Western Europe.  The API for cancer market in Asia-Pacific has been segmented into Japan, China, India, South Korea, Australia, and the rest of Asia-Pacific. The global Myelodysplastic Syndrome drugs market in the Middle East & Africa has been segmented into the Middle East and Africa.

Key Players

Various players operate in the global API for cancer market such as AbbVie, Pfizer Inc, Boehringer Ingelheim International GmbH, AstraZeneca, Novartis AG., F. Hoffmann-La Roche AG, Bayer AG, Bristol-Myers Squibb Company, Eisai Co., Ltd, Johnson & Johnson, Merck & Co. Inc., Amgen Inc., and others.

 

Febrile Seizures Market Opportunities, Sales, Cost and Profit By 2027

 Market Highlights

A Febrile Seizure is also known as a fever fit or febrile convulsion, characterized by high body temperature. The condition is most common in children between the ages of 6 months and 5 years. Febrile seizures occur in 2%-4% of children younger than five years old.

A number of factor such as growing public awareness, technological advancements, increasing the incidence of neurological disorders, unmet medical needs, increasing government assistance, rising healthcare expenditure, improving regulatory framework, and raising funding and reimbursement are propelling the growth of the global febrile seizures market.

However, challenges in the research and development, side-effects of treatment, the presence of misbranded and spurious drugs, and poor healthcare system in low and middle-income countries may hamper the growth of the market.

It is estimated that the febrile seizures market is expected to grow at a CAGR 5.5% during the forecast period of 2017-2023.

Regional Analysis

The Americas dominate the febrile seizures market owing to the rising awareness among people, and high healthcare expenditure. According to the Centers for Disease Control and Prevention in 2015, the total health expenditure in the United States was reported to be USD 3.2 trillion and hospital care accounted for a share of 32.3%.

Europe holds the second position in the febrile seizures market. It is expected that the support provided by the government bodies for research & development and improvement in reimbursement policies in the healthcare is likely to drive the European market growth.

The Asia Pacific is the fastest growing febrile seizures market owing to a huge patient pool and developing healthcare technology. Healthcare expenditure is also improving in various Asia Pacific countries. According to the Australian Institute of Health and Welfare in the years 2015-2016, the total health expenditure was USD 170.4 billion, which is 3.6% higher than the expenditure of 2014-2015.

The Middle East & Africa holds the least market share of the global market due to lack of technical knowledge and poor medical facilities.

Segmentation

The global febrile seizures market is segmented on the basis of type, diagnosis, treatment, and distribution channels.

On the basis of the type, the market is classified as simple febrile seizure and complex febrile seizure.

On the basis of the diagnosis, the market is classified as physical examination, laboratory tests, electroencephalogram (EEG), and others. The laboratory tests are further segmented into blood tests, urine tests, and lumbar puncture.

On the basis of the treatment, the market is classified as home management, antipyretic medication, and others.

On the basis of the distribution channel, the market is segmented into hospitals, clinics, diagnostic centers, drug stores, pharmacies, and others.

Key Players

Some of the key players in the global febrile seizures market are Sanofi, Cardinal Health, Merck, Pfizer, Johnson & Johnson, Abbott Laboratories, GlaxoSmithKline plc, Cephalon Inc., Shire, and UCB S.A, and others.

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Chorea Market SWOT Analysis, Demand and Emerging Trends To 2027

 Market Highlights

Chorea is a nonrhythmic, rapid, nonsuppressible involuntary movement. Chorea is often worsened by anxiety, stress and subsides during sleep. It is also found that most patients attempt to disguise chorea by a purposeful activity. Sydenham’s chorea is the most common form of chorea in childhood, whereas Huntington’s disease, and drug induced chorea found mostly in adult onset cases.

A number of factor such as growing public awareness, and technological advancements, rising prevalence of neurological disorders, increasing awareness, improving regulatory framework, increasing government assistance, increasing adoption rate, and rising funding and reimbursement policies are propelling the growth of the global chorea market.

However, challenges in research and development, side-effects of treatment, cost of treatment, the presence of misbranded and spurious drugs and poor healthcare system in low and middle-income countries may hamper the growth of the market.

It is estimated that the Chorea Market is expected to grow at a CAGR 11.4% during the forecast period of 2017-2023.

Regional Analysis

The Americas dominate the chorea market owing to the rising awareness among people, and high healthcare expenditure. According to the Centers for Disease Control and Prevention in 2015, the total health expenditure in the United States was reported to be USD 3.2 trillion and hospital care accounted for a share of 32.3%.

Europe holds the second position in the chorea market. It is expected that the support provided by the government bodies for research & development and improvement in reimbursement policies in the healthcare is likely to drive the market of Europe region.

Asia Pacific is the fastest growing chorea market owing to a huge patient pool and developing healthcare technology. Healthcare expenditure is also improving in various Asia Pacific countries. According to the Australian Institute of Health and Welfare in the years 2015-2016, the total health expenditure was USD 170.4 billion, which is 3.6% higher than the expenditure of 2014-2015.

The Middle East & Africa holds the lowest market due to lack of technical knowledge and poor medical facilities.

Segmentation

The Global Chorea Market is segmented on the basis of type, treatment, and distribution channels.

On the basis of the type, the market is classified as Huntington’s disease, Rheumatic (Sydenham’s chorea), and Drug-induced chorea.

On the basis of the treatment, the market is classified as medical care, and surgical care. The medical care is further segmented into neuroleptics, dopamine-depleting agents, GABAergic drugs, coenzyme Q10, intravenous immunoglobulin, and plasmapheresis. The sub segments neuroleptic includes, typical neuroleptics, and atypical neuroleptics. The surgical care is further segmented into deep brain stimulation, and cell transplantation.

On the basis of the distribution channel, the market is segmented into hospitals, clinics, diagnostic centers, drug stores, pharmacies, and others.

Key Players

Some of key the players in the global chorea market are Teva Pharmaceutical Industries Ltd., Valeant, Medtronic, Alnylam Pharmaceuticals, Inc., Cyberonics, Inc., AmpliPhi Biosciences Corp, Ceregene Inc., Boston Scientific Corporation, GlaxoSmithKline plc, Lundbeck, Prana Biotechnology Limited, Cortex Pharmaceuticals Inc., Vertex Pharmaceuticals Incorporated, SOM Biotech, Raptor Pharmaceutical, Omeros, Ipsen, Pfizer, Palobiofarma, Aleva Neurotherapeutics SA, and others.

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